This book provides updated information on certain in vitro and preclinical in vivo cancer models. The topics covered include an update on advancements in the diagnosis, treatment and heterogeneity in certain cancers; the development of preclinical in vitro and xenograft-based in vivo cancer models as well as their validation based on widely accepted biomarkers; modelling of aberrations in bioenergetics in cancers. Also, the importance and latest advances of in silico modeling for the design of new and potent anti-cancer drugs has been reviewed. Cutting-edge and resourceful, this book is valuable for researchers, academicians, and professionals involved in cancer research.