The book presents papers from the 6th International Conference on Big Data and Cloud Computing Challenges (ICBCC 2019), held at the University of Missouri, Kansas City, USA, on September 9 and 10, 2019 and organized in collaboration with VIT Chennai. The book includes high-quality, original research on various aspects of big data and cloud computing, offering perspectives from the industrial and research communities on how to address the current challenges in the field. As such it is a valuable reference resource for researchers and practitioners in academia and industry.