This book gathers outstanding research papers presented at the 2nd International Conference on Frontiers in Computing and Systems (COMSYS 2021), organized by Department of Electronics and Communication Engineering and Department of Information Technology, North-Eastern Hill University, Shillong, Meghalaya, India held during September 29–October 1, 2021. The book presents the latest research and results in various fields of machine learning, computational intelligence, VLSI, networks and systems, computational biology, and security, making it a rich source of reference material for academia and industry alike.