This book features high-quality research papers presented at the 2nd International Conference on Sustainable Expert Systems (ICSES 2021), held in Nepal during September 17–18, 2021. The book focusses on the research information related to artificial intelligence, sustainability, and expert systems applied in almost all the areas of industries, government sectors, and educational institutions worldwide. The main thrust of the book is to publish the conference papers that deal with the design, implementation, development, testing, and management of intelligent and sustainable expert systems and also to provide both theoretical and practical guidelines for the deployment of these systems.