This report discusses progress made by the Central Asia Regional Economic Cooperation (CAREC) Program’s trade facilitation efforts from 2010 to 2020 and evaluates the efficiency of cross-border trade across six CAREC transport corridors. Using the results of Corridor Performance Measurement and Monitoring (CPMM) tool, it outlines the disruption caused by COVID-19 and details steps by the 11 CAREC member countries to facilitate trade, bolster cooperation, and boost connectivity. Analyzing outstanding challenges and opportunities, it prescribes possible actions to remove important structural barriers to enable the efficient flow of goods and unlock growth for the region.