This volume is a collection of fresh and novel contributions to regional science. They commemorate the scientific inheritance of the founding father of regional science, the late Walter Isard. All papers are written by well-known scholars in the field and serve to highlight the great importance of regional science theory and methodology for a better understanding of current spatial and environmental problems throughout our planet. The book showcases a multidisciplinary panorama of modern regional science research and presents new insights by applying regional science approaches.