Sample Size Calculations in Clinical Research

Sample Size Calculations in Clinical Research

by Yuliya LokhnyginaHansheng Wang Shein-Chung Chow and others
Epub (Kobo), Epub (Adobe)
Publication Date: 15/08/2017

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Praise for the Second Edition:


"… this is a useful, comprehensive compendium of almost every possible sample size formula. The strong organization and carefully defined formulae will aid any researcher designing a study." -Biometrics


"This impressive book contains formulae for computing sample size in a wide range of settings. One-sample studies and two-sample comparisons for quantitative, binary, and time-to-event outcomes are covered comprehensively, with separate sample size formulae for testing equality, non-inferiority, and equivalence. Many less familiar topics are also covered …" – Journal of the Royal Statistical Society


Sample Size Calculations in Clinical Research, Third Edition presents statistical procedures for performing sample size calculations during various phases of clinical research and development. A comprehensive and unified presentation of statistical concepts and practical applications, this book includes a well-balanced summary of current and emerging clinical issues, regulatory requirements, and recently developed statistical methodologies for sample size calculation.


Features:




  • Compares the relative merits and disadvantages of statistical methods for sample size calculations


  • Explains how the formulae and procedures for sample size calculations can be used in a variety of clinical research and development stages


  • Presents real-world examples from several therapeutic areas, including cardiovascular medicine, the central nervous system, anti-infective medicine, oncology, and women’s health


  • Provides sample size calculations for dose response studies, microarray studies, and Bayesian approaches


This new edition is updated throughout, includes many new sections, and five new chapters on emerging topics: two stage seamless adaptive designs, cluster randomized trial design, zero-inflated Poisson distribution, clinical trials with extremely low incidence rates, and clinical trial simulation.

ISBN:
9781351727112
9781351727112
Category:
Probability & statistics
Format:
Epub (Kobo), Epub (Adobe)
Publication Date:
15-08-2017
Language:
English
Publisher:
CRC Press

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