This revision provides guidance to States and their competent authorities on how to establish or improve, implement, maintain and sustain the elements of the nuclear security regime related to radioactive material, associated facilities and activities, with particular emphasis on the development of regulatory requirements. The publication applies to the security of radioactive material in use or in storage, as well as associated facilities and associated activities, and assists Member States in their regimes against unauthorized removal of the radioactive material or sabotage performed with the intent to cause harmful radiological consequences.