This book presents high-quality papers from the Third International Conference on Smart Computing and Informatics (SCI 2018−19), organized by the School of Computer Engineering and School of Computer Application, Kalinga Institute of Industrial Technology Deemed to be University, Bhubaneswar, from 21 to 22 December 2018. It includes advanced and multi-disciplinary research on the design of smart computing and informatics, focusing on innovation paradigms in system knowledge, intelligence and sustainability that have the potential to provide realistic solutions to various problems in society, the environment and industry. The papers featured provide a valuable contribution to the deployment of emerging computational and knowledge transfer approaches, optimizing solutions in varied disciplines of science, technology and health care.