On his deathbed, the popular prophet Nostradamus recounts his past to a young visitor, eager for guidance on his path to fame. In his rollicking, comical tale, Nostradamus wanders across Europe, trading saintly relics like baseball cards, overcoming a confrontation with the town doctor, running into Henry VIII, facing off against a witch, being mistaken for a messiah and surviving a deadly standoff in Germany. With his cohort Ernest, a smooth-talking rascal, Nostradamus inhales nutmeg fumes and foresees chaos and laughs across the centuries.