This, the 24th issue of Transactions on Large-Scale Data- and Knowledge-Centered Systems, contains extended and revised versions of seven papers presented at the 25th International Conference on Database and Expert Systems Applications, DEXA 2014, held in Munich, Germany, in September 2014. Following the conference, and two further rounds of reviewing and selection, six extended papers and one invited keynote paper were chosen for inclusion in this special issue. Topics covered include systems modeling, similarity search, bioinformatics, data pricing, k-nearest neighbor querying, database replication, and data anonymization.