Following the events of "Vampire War: Resistance," the task force is alerted to the arrival of The Four, initially believed to help their cause in defeating the vampires, but research shows that the group will arrive to grant the master vampire, Suraya, a greater power than ever before, more than any vampire has held at any time in history. As the insertion team rushes to find them, the government sets up a group to begin building resistance groups around the country, but the effort is stalled by the trial of the traitor that allowed the walled town of Sanctuary to be invaded. The insertion team, aided by a resistance group in New Orleans and the return of the werewolf pack, including new members, move to destroy the blood farms operating around New Orleans then attack the stronghold of the vampires in a last ditch effort to destroy the master.