Chapter 1
Dynamics of Assembly and Reorganization of Extrac ellular Matrix Proteins
Sarah L. Dallas, Qian Chen and Pitc humani Sivakumar

Chapter 2
Selec tive Neuronal Degeneration in Huntington s Disease
Catherin e M. Cowan and Lynn A. Raymond

Chapter 3
RNAi Therapy for Neurodegenerative Diseases
Ryan L . Boudreau, Beverly L. Davidson

Chapter 4
Fibrillins: from biogenesis of microfibrils to signaling func tions
Dirk Hubmacher, Kerstin Tiedemann, Dieter P. Reinhard t

Chapter 5
Proteasomes from Str ucture to Function: Perspectives from Archaea
Julie A. Mau pin-Furlow, Matthew A. Humbard, P. Aaron Kirkland, Wei Li, Christopher J . Reuter, Amy J. Wright and G. Zhou

Chapter 6
The cytomatrix as a cooperative system of macromolecular a nd water networks.
V.A. Sheperd

Chapter 7
Intracellular Targeting of Phosphodiesterase-4 un