This volume contains the proceedings of the AMS Special Session on Nonstandard Finite-Difference Discretizations and Nonlinear Oscillations in honor of Ronald Mickens's 70th birthday held January 9-10 2013 in San Diego CA. Included are papers on design and analysis of discrete-time and continuous-time dynamical systems arising in the natural and engineering sciences in particular the design of robust nonstandard finite-difference methods for solving continuous-time ordinary and partial differential equation models the analytical and numerical study of models that undergo nonlinear oscillations as well as the design of deterministic and stochastic models for epidemiological and ecological processes.Some of the specific topics covered in the book include the analysis of deterministic and stochastic SIR-type models the assessment of cost-effectiveness of vaccination problems finite-difference methods for oscillatory dynamical systems (including the Schrodinger equation and Brusselator system) the design of exact and elementary stable finite-difference methods the study of a two-patch model with Allee effects and disease-modified fitness the study of the delay differential equation model with application to circadian rhythm and the application of some special functions in the solutions of some problems arising in the natural and engineering sciences. A notable feature of the book is the collection of some relevant open problems intended to help guide the direction of future research in the area.