The authors examine the relationship between the cultural, religious and social situation of German Jews on the one hand and their scientific activities on the other. They discuss the sensitive question of the specificity of the approaches of Jewish scientists and draw attention to the debate concerning the relationship between Judaism and academic research, ranging from the early 19th century theorizing on science and Judaism to 20th century issues, e.g. the controversies on 'Jewish' physics, mathematics etc. in the 1920s and 30s. Contributors: Ute Deichmann, Anthony S. Travis, Moritz Epple, Raphael Falk, Ulrich Charpa, Nurit Kirsch, Yael Hashiloni-Dolev, Aharon Loewenstein, Ruth Sime, Simone Wenkel