This book constitutes the refereed proceedings of the 15th International Conference on Detection of Intrusions and Malware, and Vulnerability Assessment, DIMVA 2018, held in Saclay, France, in June 2018. The 17 revised full papers and 1 short paper included in this book were carefully reviewed and selected from 59 submissions. They present topics such as malware analysis; mobile and embedded security; attacks; detection and containment; web and browser security; and reverse engineering.