The Septuagint's 4ᵗʰ Kingdoms tells the history of the kingdoms of Samaria and Judah from circa 850 BC until the Babylonians conquered Judah circa 600 BC. This era of history is well documented in the historical records of the Assyrians, Egyptians, and Babylonians, and unlike the earlier books of the Kingdoms, is generally accepted by historians. This era included the rise and fall of the Aramean Empire based in Damascus, the rise and fall of the Assyrian Empire farther north, the Assyrian wars against Egypt, and the sack of Thebes, and ultimately the rise of the Babylonian Empire. During this tumultuous time, the kingdoms of Israel, Judah, and Aram, which also appears to have been considered an Israelite kingdom by the prophet Ezekiel, struggled for survival and fell one by one to the expanding empires around them.

Before the era of 4ᵗʰ Kingdoms, Samara had established an empire, occupying the Aramean kingdoms of Damascus and Hama in modern Syria, which had ended suddenly when an earthquake had leveled Samaria. The earthquake was mentioned in the Book of Amos, and archaeological evidence of it is found throughout modern northern Israel and the Palestinian West Bank. It is estimated to have been between 7.8 and 8.2 on the Richter Scale, and aftershocks likely lasted around 6 months. In the aftermath, Damascus rose to form its own Aramean empire, occupying Hama, and northern Samaria, as well as Gilead in southern modern Syria, which had been part of Samaria since the division of Israel into Samaria and Judah. However, as Assyria began to expand to the north, Samaria and Aram formed an anti-Assyria alliance, and the Samarian forces were stationed in Aram to help defend the northern border from the Assyrians. Judah was invited to join the alliance, but instead formed an alliance with the Assyrians and invaded and pillaged Samaria and southern Aram.

Judah continued to be an ally of Assyria as the Assyrians conquered Aram, Samaria, and Sidon which had also allied with them. Fortunately, as Samaria finally fell to the Assyrians after a three-year campaign, the king of Assyria died, sparking a civil war between rival heirs. This civil war provided Judah with almost twenty years to build up defenses, and King Hezekiah built extensively across his kingdom. Archaeological evidence of Hezekiah's construction projects is common in the region around Jerusalem, and the southern region of the Palestinian West Bank, including the Broad Wall in Jerusalem, and the Siloam Tunnel, which connected Jerusalem with a water source outside the walls of the city. Ancient records of anti-siege artillery on the walls of Jerusalem also exist, likely ballistas or catapults, so, it is clear the Judahites knew they would be next. While the Assyrians did lay siege to Jerusalem according to 4ᵗʰ Kingdoms, they were not able to conquer the city. The Assyrian Annals record the campaign against Judah and record the cities they captured, which did not include Jerusalem, and so historians accept the general account of what happened found in 4ᵗʰ Kingdoms.